Description

1-(4-Fluoro-Phenyl)-But-3-En-2-One is a high-purity fluorinated organic building block, specifically an α,β-unsaturated ketone, with the CAS number 860642-35-9. This compound is valued for its versatile reactivity, serving as a key synthon for constructing complex molecular architectures in advanced chemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and ligands for studying biological mechanisms and drug discovery.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.
• Conjugate Addition Substrate: The α,β-unsaturated ketone moiety is ideal for Michael addition reactions, enabling diverse functionalization.

Basic Information

Product Name	1-(4-Fluoro-Phenyl)-But-3-En-2-One
CAS No.	860642-35-9
Molecular Formula	C10H9FO
Molecular Weight	164.18 g/mol
Synonyms	4'-Fluoro-3-buten-2-one; 4-Fluorophenyl vinyl ketone; 1-(4-Fluorophenyl)-3-buten-2-one; (4-Fluorophenyl)vinyl ketone; 4-Fluorobenzalacetone; 4-Fluoro-β-methylstyryl ketone; 3-Buten-2-one, 1-(4-fluorophenyl)-; 860642-35-9
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-Phenyl)-But-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.