Description

2,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole is a high-value organoboron building block, specifically a boronic ester derivative of a substituted thiazole. This compound matters for its critical role as a key intermediate in modern synthetic chemistry, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the thiazole heterocycle.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific thiazole-based structures.
• Material Science Research: Serves as a monomer or precursor for developing organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner to introduce the 2,4-dimethylthiazol-5-yl moiety into target molecules.
• Chemical Biology & Proteomics: Utilized in the synthesis of chemical probes and bioconjugates for studying biological processes.
• Ligand Synthesis for Catalysis: Acts as a precursor for creating novel nitrogen-sulfur (N,S) bidentate ligands used in transition metal catalysis.

Basic Information

Product Name	2,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
CAS No.	859833-13-9
Molecular Formula	C11H18BNO2S
Molecular Weight	239.15 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dimethylthiazole; 2,4-Dimethylthiazole-5-boronic acid pinacol ester; 2,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2,4-Dimethylthiazol-5-ylboronic acid pinacol ester; 859833-13-9; (2,4-Dimethyl-1,3-thiazol-5-yl)boronic acid pinacol ester; Pinacol 2,4-dimethyl-1,3-thiazole-5-boronate
EINECS	Contact for details

Quality Control

Our production of 2,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR (1H, 13C, 11B), HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical: 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.