Description

2-Bromo-4-Ethynyl-1-Methoxybenzene is a versatile aromatic building block featuring both bromo and ethynyl functional groups. This compound is valued for its role in advanced organic synthesis, particularly in cross-coupling reactions and as a precursor for complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Material Science: Used in the creation of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated structure.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed coupling reactions to construct complex biaryl and aryl-alkyne systems.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes via click chemistry.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry and scale-up process optimization.

Basic Information

Product Name	2-Bromo-4-Ethynyl-1-Methoxybenzene
CAS No.	859211-28-2
Molecular Formula	C9H7BrO
Molecular Weight	211.06 g/mol
Synonyms	1-Bromo-2-methoxy-4-ethynylbenzene; 4-Ethynyl-2-bromoanisole; 2-Bromo-4-ethynylanisole; 2-Methoxy-5-bromophenylacetylene; 5-Bromo-2-methoxyphenylacetylene; Benzene, 2-bromo-4-ethynyl-1-methoxy-; (2-Bromo-4-methoxyphenyl)acetylene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Ethynyl-1-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.