Description

2,2,2-Trifluoro-1-(5-Methyl-3-Indolyl)Ethanone is a specialized fluorinated indole derivative, a high-value building block in advanced organic synthesis. Its core value lies in the trifluoroacetyl group attached to the indole scaffold, which is instrumental in modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a starting material for synthesizing functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoroacetyl moiety into complex molecular architectures in academic and industrial research settings.
• Biochemical Probe Development: Utilized in creating labeled compounds and probes for studying biological mechanisms and enzyme interactions.

Basic Information

Product Name	2,2,2-Trifluoro-1-(5-Methyl-3-Indolyl)Ethanone
CAS No.	858515-93-2
Molecular Formula	C11H8F3NO
Molecular Weight	227.18 g/mol
Synonyms	1-(5-Methyl-1H-indol-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-methyl-1H-indol-3-yl)ethanone; 5-Methyl-3-trifluoroacetylindole; 3-Trifluoroacetyl-5-methylindole; 2,2,2-Trifluoro-1-(5-methylindol-3-yl)ethanone; TFMI; Trifluoroacetyl-5-methylindole
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(5-Methyl-3-Indolyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.