Description

3-Iodo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine is a high-value, multi-functional heterocyclic building block that combines a pyridine core with both an iodine substituent and a pinacol boronate ester group. This unique bifunctional structure makes it a critical intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex, functionalized biaryl and heterobiaryl systems. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and organic electronic components.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and CNS drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science Research: Serves as a precursor for creating organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other functional organic electronic materials.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated pyridine-based ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for proteomics and diagnostic assay development.
• Academic & Contract Research: Essential reagent for synthetic organic chemistry research in universities and CROs exploring new coupling methodologies.

Basic Information

Product Name	3-Iodo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine
CAS No.	857934-93-1
Molecular Formula	C11H15BINO2
Molecular Weight	331.0 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-iodopyridine; 3-Iodo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (3-Iodopyridin-5-yl)boronic acid pinacol ester; 5-Iodo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Iodo-5-pyridineboronic acid pinacol ester; Pyridine, 3-iodo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 857934-93-1; Boronic acid, B-(3-iodo-5-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Iodo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity for sensitive cross-coupling applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, assay, and impurity profile is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.