Description

2-(2-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically an iodophenyl-substituted boronic ester. This compound is critical for enabling complex molecular construction via cross-coupling reactions, offering a precise handle for introducing functionalized aromatic systems. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key coupling partner with various aryl/heteroaryl halides for constructing biaryl and heterobiaryl scaffolds, a fundamental transformation in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing iodine-substituted phenyl motifs which can be further functionalized.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides that require specific halogenated aromatic structures.
• Material Science Research: Acts as a precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics, where the iodine allows for subsequent structural elaboration.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and tags where the boronic ester and iodine functionalities enable selective conjugation and labeling.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences industry for producing non-commercial, proprietary compounds.

Basic Information

Product Name	2-(2-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	857934-82-8
Molecular Formula	C12H16BIO2
Molecular Weight	330.0 g/mol
Synonyms	2-(2-Iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Iodophenyl)boronic acid pinacol ester; 2-Iodophenylboronic acid pinacol ester; 1-Iodo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 2-Iodo-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 2-Iodophenyl-Bpin; B-(2-Iodophenyl)pinacolborane
EINECS	Contact for details

Quality Control

Our production of 2-(2-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed via NMR (1H, 13C, 11B), HPLC, and GC to confirm identity and quantify purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.