Description

1-Bromo-4-(1-Fluoro-1-Methyl-Ethyl)-Benzene is a high-purity halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromine and a fluorinated tertiary butyl group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as Suzuki cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura coupling, enabling the efficient construction of biaryl systems central to many functional molecules.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Design: The steric bulk of the (1-fluoro-1-methylethyl) group makes it useful for synthesizing specialized ligands for asymmetric catalysis.

Basic Information

Product Name	1-Bromo-4-(1-Fluoro-1-Methyl-Ethyl)-Benzene
CAS No.	857293-81-3
Molecular Formula	C9H10BrF
Molecular Weight	217.08 g/mol
Synonyms	1-Bromo-4-(1-fluoro-1-methylethyl)benzene; 4-Bromo-α,α-dimethylbenzyl fluoride; p-Bromo-α,α-dimethylbenzyl fluoride; 1-Bromo-4-(2-fluoro-2-propyl)benzene; (4-Bromophenyl)(1-fluoro-1-methylethyl)methane; 2-(4-Bromophenyl)-2-fluoropropane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for parameters such as assay (by GC/HPLC), identity (by IR/NMR), and impurity profile are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (GC/HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.