Description

1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidine is a high-value, synthetically versatile organoboron building block, specifically a pinacol boronate ester derivative. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures in modern organic synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl and heterobiaryl motifs via palladium-catalyzed cross-couplings.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-pyrrolidine or complex aromatic structures.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, where precise molecular structure is critical.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biochemical assays and diagnostic research due to its reactive boronate handle.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic laboratories and contract research organizations (CROs).
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects where reliable, gram-to-kilogram scale material is needed for process optimization and pilot plant studies.

Basic Information

Product Name	1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidine
CAS No.	857283-63-7
Molecular Formula	C16H24BNO2
Molecular Weight	273.18 g/mol
Synonyms	3-(Pyrrolidin-1-yl)phenylboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine; 3-(1-Pyrrolidinyl)benzeneboronic acid pinacol ester; 3-Pyrrolidin-1-ylbenzeneboronic acid pinacol ester; N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine; 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine; 3-Pyrrolidinophenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. Each lot is analyzed using advanced techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent hydrolysis of the boronate ester. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.