Description

4-Hydroxyphenylglyoxal Hydrate is a versatile aromatic α-dicarbonyl compound, serving as a key synthetic intermediate and biochemical reagent. Its unique chemical structure, featuring both a phenolic hydroxyl and a reactive glyoxal moiety, makes it valuable for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors, particularly for the synthesis of heterocycles and advanced organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with heterocyclic frameworks.
• Bioconjugation & Crosslinking Agent: Utilized in biochemical research for modifying proteins, peptides, and other biomolecules due to its reactive carbonyl groups.
• Fine Chemical Synthesis: Serves as a precursor for dyes, pigments, and advanced organic materials requiring specific aromatic-aldehyde functionality.
• Agrochemical Research: Used in the development and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probe Development: Acts as a scaffold for creating molecular probes to study enzyme activity and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	4-Hydroxyphenylglyoxal Hydrate
CAS No.	854670-84-1
Molecular Formula	C8H8O4 • xH2O
Molecular Weight	168.15 (Anhydrous basis)
Synonyms	(4-Hydroxyphenyl)glyoxal Hydrate; 2-Oxo-2-(4-hydroxyphenyl)acetaldehyde Hydrate; 4-Hydroxybenzoylformaldehyde Hydrate; p-Hydroxyphenylglyoxal Hydrate; 4-HPG Hydrate; 4-Hydroxymandelaldehyde Hydrate (tautomer); 1-(4-Hydroxyphenyl)-1,2-ethanedione Hydrate
EINECS	Contact for details

Quality Control

Our 4-Hydroxyphenylglyoxal Hydrate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with key parameters including assay (HPLC), water content (KF), and identification (IR, NMR). Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider under an inert atmosphere. Keep away from strong oxidizing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Melting Point	Contact for details
Heavy Metals (as Pb)	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.