Description

1,3,2-Dioxaborolane, 2-[4-[(2-Chlorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering superior stability and handling characteristics compared to its free acid form, which is critical for reliable and reproducible cross-coupling reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl or vinyl halides and boronic acids, a cornerstone reaction in medicinal chemistry and material science.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Advanced Material Development: Employed in the creation of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers where precise molecular structure is paramount.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Its enhanced stability makes it suitable for optimizing and scaling up synthetic routes from laboratory to pilot plant and manufacturing scales.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[4-[(2-Chlorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	854371-84-9
Molecular Formula	C19H22BClO3
Molecular Weight	344.64 g/mol
Synonyms	2-(4-((2-Chlorophenoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-[(2-Chlorophenoxy)methyl]phenylboronic acid pinacol ester; [4-[(2-Chlorophenyl)methoxy]phenyl]boronic acid pinacol ester; 2-Chlorobenzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; (4-((2-Chlorobenzyl)oxy)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane derivative is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.