Description

2-[4-Amino-3-(Trifluoromethyl)Phenyl]Acetonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its reactive amino and cyano groups. This compound matters for its critical role in the synthesis of complex heterocyclic systems and active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce a trifluoromethylated aniline moiety into their molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule drugs.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and pesticides leveraging the biological activity of the trifluoromethyl group.
• Ligand and Catalyst Development: Used to create novel chelating ligands and organocatalysts for asymmetric synthesis.
• Advanced Material Research: Monomer or precursor for functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Serves as a starting point for developing fluorescent tags or activity-based probes for enzyme studies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	2-[4-Amino-3-(Trifluoromethyl)Phenyl]Acetonitrile
CAS No.	854273-16-8
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	4-Amino-3-(trifluoromethyl)benzyl cyanide; 2-(4-Amino-3-(trifluoromethyl)phenyl)acetonitrile; 3-(Trifluoromethyl)-4-aminobenzyl cyanide; 4-Amino-α-(trifluoromethyl)benzenecetonitrile; (4-Amino-3-(trifluoromethyl)phenyl)acetonitrile; 2-(4-Amino-3-trifluoromethylphenyl)acetonitrile; 854273-16-8
EINECS	Contact for details

Quality Control

Our 2-[4-Amino-3-(Trifluoromethyl)Phenyl]Acetonitrile is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.