Description

Pyrrolidine, 2-Ethynyl- is a high-value, nitrogen-containing heterocyclic building block featuring a reactive ethynyl (acetylene) substituent. This unique molecular architecture makes it a critical intermediate for constructing complex pharmacophores and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Medicinal Chemistry Scaffold: Used to introduce the pyrrolidine ring system and an alkyne "handle" for click chemistry (e.g., Huisgen cycloaddition) in drug discovery and bioconjugation.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Ligand Synthesis: Acts as a precursor for creating specialized ligands in catalysis and coordination chemistry.
• Material Science Building Block: Utilized in the development of functional polymers, dendrimers, and other advanced organic materials.
• Chemical Biology Probes: The alkyne group enables labeling and pull-down experiments to study protein interactions and cellular pathways.

Basic Information

Item	Detail
Product Name	Pyrrolidine, 2-Ethynyl-
CAS No.	853304-19-5
Molecular Formula	C6H9N
Molecular Weight	95.14 g/mol
Synonyms	2-Ethynylpyrrolidine; 2-Ethynyl-1-azacyclopentane; 1-Azacyclopentane, 2-ethynyl-; 2-Ethynylazacyclopentane; Pyrrolidine, 2-ethynyl- (9CI); 853304-19-5 (CAS RN)
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 2-Ethynyl- is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.