Description

1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Piperidine is a high-value, synthetically versatile organoboron building block essential for modern cross-coupling reactions. This compound matters because it provides a protected boronic acid derivative, offering superior stability and handling characteristics compared to its free acid form, which is critical for reliable and scalable synthesis. Pharmaceutical, agrochemical, and advanced materials researchers need this intermediate for the efficient construction of complex molecules, particularly in Suzuki-Miyaura couplings to form new carbon-carbon bonds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing a biaryl or substituted phenylpiperidine scaffold.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-piperidine motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs or conductive polymers, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable boron reagent for palladium-catalyzed coupling with various organic halides, enabling the formation of biaryl structures.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for biological target identification and study.
• Academic & Contract Research: A fundamental reagent for synthetic organic chemistry research in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Piperidine
CAS No.	852227-97-5
Molecular Formula	C17H26BNO2
Molecular Weight	287.21 g/mol
Synonyms	3-(Piperidin-1-yl)phenylboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine; 3-(1-Piperidinyl)benzeneboronic acid pinacol ester; 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine; 3-Piperidin-1-ylbenzeneboronic acid pinacol ester; 852227-97-5; B-3-Piperidin-1-ylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, 1H/13C NMR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.