Description

3H-Diazirine-3-Propanoic Acid, α-Amino-3-Methyl- is a specialized heterocyclic compound featuring a reactive diazirine photoaffinity label and an amino acid-like backbone. This unique structure makes it a critical intermediate for the synthesis of photoactivatable cross-linking reagents used in advanced biochemical research. It is essential for scientists and manufacturers developing probes for studying protein-protein interactions, ligand-receptor binding, and other complex biomolecular structures. The compound is supplied with the CAS number 851960-84-4.

Application

• Photoaffinity Labeling (PAL) Probes: A key building block for synthesizing photoactivatable cross-linkers to capture transient biomolecular interactions.
• Chemical Biology Research: Used in the development of activity-based protein profiling (ABPP) reagents and other chemical tools for proteomics.
• Pharmaceutical Development: Serves as an intermediate in creating novel drug candidates that utilize covalent binding mechanisms.
• Bioconjugation: Enables the site-specific labeling of proteins, antibodies, and other biomolecules for imaging and diagnostic applications.
• Material Science: Potential use in creating photo-responsive polymers and smart surfaces.

Basic Information

Item	Detail
Product Name	3H-Diazirine-3-Propanoic Acid, α-Amino-3-Methyl-
CAS No.	851960-84-4
Molecular Formula	C5H7N3O2
Molecular Weight	141.13 g/mol
Synonyms	3-(3-Methyl-3H-diazirin-3-yl)-2-aminopropanoic acid; 2-Amino-3-(3-methyl-3H-diazirin-3-yl)propanoic acid; L-Photo-Leucine analogue; Photoactivatable amino acid; Diazirine-modified leucine; 3-Methyl-3H-diazirine-3-propanoic acid, α-amino-; Methyl-diazirine-AA
EINECS	Contact for details

Quality Control

Our production of 3H-Diazirine-3-Propanoic Acid, α-Amino-3-Methyl- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive and hygroscopic; all handling and aliquoting should be performed under controlled conditions to minimize exposure to light and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.