Description

Cysmethynil CAS NO 851636-83-4 is a potent and selective small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), a key enzyme in the post-translational modification and activation of Ras and other CaaX proteins. This compound is a critical research tool for investigating the role of protein prenylation in cellular signaling pathways, particularly those involved in oncogenesis and cell proliferation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on cancer biology, signal transduction, and the development of novel therapeutic agents targeting Ras-driven cancers.

Application

• Cancer Research: Used as a biochemical tool to study Ras protein localization, function, and signaling in various cancer cell lines and models.
• Signal Transduction Studies: Investigates the role of ICMT and protein prenylation in critical cellular pathways, including proliferation, differentiation, and survival.
• Drug Discovery & Development: Serves as a reference compound or lead structure in high-throughput screening and medicinal chemistry programs aimed at developing novel oncology therapeutics.
• Academic & Preclinical Research: Employed in university and institutional labs for fundamental biological research into post-translational modifications and their disease implications.
• Biomarker Research: Aids in understanding the biochemical consequences of inhibiting prenylation, which can inform the identification of predictive or pharmacodynamic biomarkers.

Basic Information

Product Name	Cysmethynil
CAS No.	851636-83-4
Molecular Formula	C₂₀H₂₀N₂O₃
Molecular Weight	336.39 g/mol
Synonyms	N-[3-[2-(1H-Indol-3-yl)ethylamino]-3-oxo-1-phenylpropyl]-1H-indole-2-carboxamide; ICMT Inhibitor II; CAS 851636-83-4; Cysmethynil (ICMT Inhibitor); Isoprenylcysteine Carboxyl Methyltransferase Inhibitor
EINECS	Contact for details

Quality Control

Our Cysmethynil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support our clients' regulatory needs with full documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.