Description

3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Indole is a high-value, multi-functional indole derivative containing a pinacol boronate ester group, serving as a critical synthetic intermediate. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in advanced organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and scalable routes to functionalized heterocyclic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, receptor modulators, and other bioactive molecules containing the indole scaffold.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides that leverage the indole structure for biological activity.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs), conductive polymers, and liquid crystals.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents due to its reactive boronate handle.
• Academic & R&D Laboratories: A versatile reagent for methodological development in cross-coupling chemistry and the exploration of new synthetic pathways.
• Scale-up Process Chemistry: Suitable for transition from milligram-scale discovery to kilogram-scale production under optimized coupling conditions.

Basic Information

Product Name	3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Indole
CAS No.	851524-90-8
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-indole; 3-Methyl-1H-indole-5-boronic acid pinacol ester; 3-Methyl-5-(pinacolatoboryl)indole; 5-Borono-3-methylindole pinacol ester; 851524-90-8; 3-Methyl-5-indoleboronic acid pinacol ester; 5-(Pinacolatoboryl)-3-methylindole
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Indole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive cross-coupling reactions and advanced synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.