Description

Racemic-(1S,3S,4S,5R)-2-(tert-Butoxycarbonyl)-5-Hydroxy-2-Azabicyclo[2.2.2]Octane-3-Carboxylic Acid (Wx120032) is a sophisticated bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique, rigid scaffold is essential for constructing complex molecular architectures with precise stereochemistry. This high-purity intermediate is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Utilized as a rigid, stereodefined scaffold to induce chirality in complex organic molecules during multi-step synthesis.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Process Chemistry & Scale-Up: Serves as a reliable starting material for the pilot and commercial-scale manufacturing of advanced intermediates under GMP conditions.
• Academic & Industrial Research: Used in methodological studies and the discovery of new synthetic routes involving constrained amino acid systems.
• Ligand & Catalyst Development: Potential precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	Racemic-(1S,3S,4S,5R)-2-(tert-Butoxycarbonyl)-5-Hydroxy-2-Azabicyclo[2.2.2]Octane-3-Carboxylic Acid (Wx120032)
CAS No.	851389-23-6
Molecular Formula	C13H21NO5
Molecular Weight	271.31 g/mol
Synonyms	(±)-2-[(tert-Butoxy)carbonyl]-5-hydroxy-2-azabicyclo[2.2.2]octane-3-carboxylic acid; 2-Azabicyclo[2.2.2]octane-3-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-, (1S,3S,4S,5R)-rel-; Boc-5-hydroxy-2-azanorbornane-3-carboxylic acid (racemic); Wx120032; Bicyclic proline derivative; tert-Butyl 5-hydroxy-3-(carboxy)-2-azabicyclo[2.2.2]octane-2-carboxylate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients' regulatory needs and are committed to meeting the stringent standards required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.