Description

2-(2,6-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a stable, protected boronic acid equivalent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted biphenyl or heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling: A versatile and widely used reagent for palladium-catalyzed carbon-carbon bond formation, facilitating the creation of complex molecular architectures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular structure is critical.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands or functionalized molecules used in catalytic systems.
• Chemical Biology Probes: Useful in the synthesis of tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Product Name	2-(2,6-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	851231-30-6
Molecular Formula	C14H21BO4
Molecular Weight	264.13 g/mol
Synonyms	2,6-Dimethoxyphenylboronic acid pinacol ester; (2,6-Dimethoxyphenyl)boronic acid pinacol ester; 2,6-Dimethoxyphenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2,6-dimethoxyphenyl)boronate; 2-(2,6-Dimethoxyphenyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; 851231-30-6; 2,6-Dimethoxybenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.