Description

1-Imidazole-4-Boronic Ester is a high-value organoboron building block, specifically a boronic ester derivative of imidazole, essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecules in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel heterocyclic compounds and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting kinase inhibition and other biological pathways.
• Agrochemical Development: Used to create advanced active ingredients for crop protection products with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for functionalized polymers, ligands for catalysis, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling Reactions: The primary application is as a versatile coupling partner for forming carbon-carbon bonds between the imidazole ring and various aryl or vinyl halides.
• Ligand Synthesis: Used to prepare specialized N-heterocyclic ligands for transition metal catalysts.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological systems.

Basic Information

Product Name	1-Imidazole-4-Boronic Ester
CAS No.	851199-70-7
Molecular Formula	C9H15BN2O2 (for common pinacol ester)
Molecular Weight	194.04 g/mol (for common pinacol ester)
Synonyms	1H-Imidazole-4-boronic acid, pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole; 1H-Imidazol-4-ylboronic acid pinacol ester; 4-Imidazoleboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)imidazole; Imidazole-4-boronic acid pinacol ester; 4-Boronimidazole pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Imidazole-4-Boronic Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support compliance with relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.