Description

2-(Benzyloxy)-5-Chloropyridin-3-Ylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyridine-chlorine scaffold for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Ligand and Catalyst Development: Employed in the creation of novel boron-containing ligands and catalysts for asymmetric synthesis and other transition metal-catalyzed reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme inhibition.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(Benzyloxy)-5-Chloropyridin-3-Ylboronic Acid
CAS No.	850864-58-3
Molecular Formula	C12H11BClNO3
Molecular Weight	263.48 g/mol
Synonyms	5-Chloro-2-(phenylmethoxy)-3-pyridineboronic acid; (5-Chloro-2-(benzyloxy)pyridin-3-yl)boronic acid; 2-Benzyloxy-5-chloropyridine-3-boronic acid; 3-Borono-5-chloro-2-(benzyloxy)pyridine; Boronic acid, B-[5-chloro-2-(phenylmethoxy)-3-pyridinyl]-; 850864-58-3; AKOS005258155
EINECS	Contact for details

Quality Control

Every batch of 2-(Benzyloxy)-5-Chloropyridin-3-Ylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, NMR, and LC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.