Description

1-Boc-6-Methoxyindole-2-Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected indole scaffold. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed carbon-carbon bond formation, enabling the rapid assembly of diverse chemical libraries.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require functionalized indole motifs.
• Material Science: Potential precursor for organic electronic materials and ligands for catalysis due to its electron-rich indole core and boronic acid functionality.
• Academic & R&D: Critical reagent for methodological studies in organic synthesis and for exploring new chemical space in hit-to-lead optimization campaigns.

Basic Information

Product Name	1-Boc-6-Methoxyindole-2-Boronic Acid
CAS No.	850568-65-9
Molecular Formula	C₁₄H₁₈BNO₅
Molecular Weight	291.11 g/mol
Synonyms	1-Boc-6-Methoxy-1H-indole-2-boronic acid; 2-Borono-6-methoxy-1-[(2-methylpropan-2-yl)oxycarbonyl]-1H-indole; 6-Methoxy-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic acid; tert-Butyl 6-methoxy-2-borono-1H-indole-1-carboxylate; 1-Boc-6-methoxyindole-2-boronic acid pinacol ester (cyclic ester); 6-Methoxy-1-Boc-indole-2-boronic Acid; 1-N-Boc-6-methoxyindole-2-boronic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Methoxyindole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (Karl Fischer)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.