Description

Ethyl 2-Boronobenzoate, Propanediol Cyclic Ester is a high-purity organoboron reagent, specifically a cyclic ester derivative of 2-boronobenzoic acid. This compound is valued for its enhanced stability and handling properties compared to simpler boronic acids, making it a crucial building block in modern synthetic chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions and the synthesis of complex organic molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common structural motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Agrochemical Development: Employed in creating advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Serves as a precursor for boron-containing polymers, liquid crystals, and organic electronic materials.
• Chemical Library Production: Utilized in parallel and combinatorial synthesis for high-throughput screening in drug discovery programs.
• Catalyst and Ligand Development: Acts as a starting material for synthesizing novel boron-based catalysts and ligands for asymmetric synthesis.

Basic Information

Product Name	Ethyl 2-Boronobenzoate, Propanediol Cyclic Ester
CAS No.	850567-60-1
Molecular Formula	C11H13BO4
Molecular Weight	220.03 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid ethyl ester; Ethyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; Benzoic acid, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; Ethyl 2-boronobenzoate cyclic ester with pinacol; 2-Boronobenzoic acid ethyl ester pinacol cyclic ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Boronobenzoate, Propanediol Cyclic Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.