Description

1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl)Ethan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a key indazole-boronic ester functional group. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation to create complex molecular architectures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and probes for target identification and validation.
• Agrochemical Intermediate: Potential use in the research and development of novel crop protection agents.
• Material Science Precursor: Exploration into organic electronic materials and metal-organic frameworks (MOFs) utilizing its conjugated structure.

Basic Information

Product Name	1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl)Ethan-1-One
CAS No.	850363-83-6
Molecular Formula	C₁₅H₁₉BN₂O₃
Molecular Weight	286.14 g/mol
Synonyms	1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl]ethanone; 1-Acetyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl Ethyl Ketone; 1-(5-(Pinacolatoboryl)-1H-indazol-1-yl)ethanone; 5-Pinacolatoboryl-1-acetylindazole; 850363-83-6; AKOS005258315; BRN 15306451
EINECS	Contact for details

Quality Control

Our 1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl)Ethan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.