Description

1-Bromo-4-(2,2-diethoxyethoxy)-2,3,5-trifluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a bromine substituent and a protected aldehyde equivalent (acetal group) on a fluorinated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronics: Employed in the research and development of organic semiconductors and charge-transport materials due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form biaryl structures.
• Acetal Deprotection: The diethoxyethoxy group can be hydrolyzed to reveal an aldehyde functionality, enabling further derivatization and chain elongation.

Basic Information

Product Name	1-Bromo-4-(2,2-diethoxyethoxy)-2,3,5-trifluorobenzene
CAS No.	850349-82-5
Molecular Formula	C12H15BrF3O3
Molecular Weight	345.15 g/mol
Synonyms	2,3,5-Trifluoro-4-bromophenylacetaldehyde diethyl acetal; 4-Bromo-2,3,5-trifluorophenylacetaldehyde diethyl acetal; 1-Bromo-4-(2,2-diethoxyethyl)-2,3,5-trifluorobenzene; Benzene, 1-bromo-4-(2,2-diethoxyethoxy)-2,3,5-trifluoro-; 850349-82-5; Acetaldehyde, 2-(4-bromo-2,3,5-trifluorophenyl)-, diethyl acetal
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(2,2-diethoxyethoxy)-2,3,5-trifluorobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.