Description

2-((3-tert-Butyldimethylsilyloxy)-1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane is a sophisticated organoboron building block featuring a protected alkyne and a pinacol boronic ester group, enabling precise cross-coupling reactions. This compound is critical for constructing complex molecular architectures where chemoselectivity and functional group tolerance are paramount. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for synthesizing novel active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for forming carbon-carbon bonds in complex molecule synthesis.
• Pharmaceutical Intermediate Synthesis: For the construction of advanced intermediates in the development of new therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Material Science Research: In the synthesis of conjugated organic molecules for applications in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Agrochemical Development: As a building block for creating novel compounds with potential biological activity for crop protection.
• Chemical Biology Probes: For the synthesis of tagged molecules used to study biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Enabling efficient, scalable routes to target molecules in pilot plant and manufacturing settings.

Basic Information

Product Name	2-((3-tert-Butyldimethylsilyloxy)-1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane
CAS No.	849820-20-8
Molecular Formula	C16H31BO3Si
Molecular Weight	310.31 g/mol
Synonyms	1-Butyn-1-ol, 3-[(1,1-dimethylethyl)dimethylsilyl]-, 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-(3-(tert-Butyldimethylsilyloxy)but-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-((tert-Butyldimethylsilyl)oxy)but-1-yn-1-yl)boronic acid pinacol ester; TBDMS-protected butynyl pinacol boronate; 849820-20-8
EINECS	Contact for details

Quality Control

Our production of 2-((3-tert-Butyldimethylsilyloxy)-1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.