Description

5-Methyl-1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because it enables efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on new active ingredients, materials, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and heterocyclic compound libraries.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific pyrazole-boronate motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED emitters and charge-transport molecules.
• Cross-Coupling Reactions: A versatile reagent for Suzuki-Miyaura coupling to form carbon-carbon bonds between aryl/heteroaryl groups.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Academic & Contract Research: A critical reagent for methodology development and complex molecule synthesis in academic and CRO laboratories.

Basic Information

Product Name	5-Methyl-1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	849776-88-1
Molecular Formula	C₁₆H₂₁BN₂O₂
Molecular Weight	284.16 g/mol
Synonyms	1H-Pyrazole, 5-methyl-1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-Methyl-1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Phenyl-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-1-phenyl-1H-pyrazole; 5-Methyl-1-phenyl-1H-pyrazole-4-boronic acid pinacol ester; 849776-88-1; Pyrazole boronic ester; Pinacol boronate pyrazole derivative.
EINECS	Contact for details

Quality Control

Our 5-Methyl-1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.