Description

2-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value, functionalized aniline derivative containing a pinacol boronate ester group, making it a versatile building block for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable intermediates for drug discovery, ligand synthesis, and polymer development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring biaryl or heterobiaryl linkages.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that leverage its boronate functionality for structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Research & Development: A crucial reagent in medicinal chemistry and process chemistry for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Used in the multi-step synthesis of complex dyes, pigments, and other specialty chemicals.

Basic Information

Product Name	2-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	849236-22-2
Molecular Formula	C₁₂H₁₇BN₂O₄
Molecular Weight	264.09 g/mol
Synonyms	2-Nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 5-Amino-2-nitrophenylboronic acid pinacol ester; (5-Amino-2-nitrophenyl)boronic acid pinacol ester; 2-Nitro-5-(pinacolatoboryl)aniline; 849236-22-2; Aniline, 2-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol (5-Amino-2-nitrophenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.