Description

1H-Pyrrolo[2,3-B]Pyridine, 1-(Methylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional chemical building block designed for advanced synthetic applications. Its core value lies in its dual functionality, combining a protected boronic ester group with a sulfonamide-substituted azaindole scaffold, enabling precise cross-coupling reactions and targeted molecular construction. This compound is essential for pharmaceutical R&D and agrochemical synthesis, where it serves as a key intermediate in the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functionality makes it an ideal partner for palladium-catalyzed coupling to construct complex biaryl and heterobiaryl structures.
• Agrochemical Research: Used in developing new active ingredients for crop protection with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry campaigns.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-(Methylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	849068-22-0
Molecular Formula	C14H19BN2O4S
Molecular Weight	322.19 g/mol
Synonyms	1-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(methylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-Methanesulfonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 849068-22-0; 5-Boronic acid pinacol ester of 1-(methylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Methylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrolo[2,3-B]Pyridine, 1-(Methylsulfonyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.