Description

Cyclobutylboronic Acid CAS NO 849052-26-2 is a versatile organoboron compound featuring a strained cyclobutyl ring, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex carbon-carbon bonds. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

Cyclobutylboronic Acid is a critical reagent in advanced organic synthesis, with key applications including:

• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those incorporating the strained, bioactive cyclobutyl moiety.
• Agrochemical Synthesis: Construction of novel herbicides, fungicides, and insecticides with enhanced properties.
• Suzuki-Miyaura Cross-Coupling: A premier reagent for palladium-catalyzed cross-coupling reactions to form biaryl and alkyl-aryl bonds.
• Material Science Research: Building block for creating organic electronic materials, liquid crystals, and polymers with specific structural features.
• Chemical Biology & Medicinal Chemistry: Used in the synthesis of molecular probes and tool compounds for target identification and validation.
• Process Chemistry & Scale-up: Suitable for development from laboratory-scale research to pilot plant and commercial manufacturing processes.

Basic Information

Product Name	Cyclobutylboronic Acid
CAS No.	849052-26-2
Molecular Formula	C4H9BO2
Molecular Weight	99.93 g/mol
Synonyms	Cyclobutylboronic Acid; Cyclobutylboronic acid (contains varying amounts of Anhydride); Cyclobutaneboronic Acid; B-Cyclobutylboronic Acid; Cyclobutyl-Boron Dihydroxide; Cyclobutylboronic acid (contains varying amounts of anhydride); Cyclobutylboronic acid (contains varying amounts of anhydride)
EINECS	Contact for details

Quality Control

Our Cyclobutylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and titration methods, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.