Description

n-(4-tert-Butylphenyl)-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized for the efficient formation of carbon-carbon bonds between aromatic rings, essential for creating complex molecular architectures.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Used in the synthesis of organic electronic materials, such as ligands for OLEDs or organic semiconductors.
• Chemical Biology Probes: Employed in the creation of tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of target molecules.

Basic Information

Item	Detail
Product Name	n-(4-tert-Butylphenyl)-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine
CAS No.	848841-47-4
Molecular Formula	C25H32BFN2O2
Molecular Weight	422.34 g/mol
Synonyms	6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[4-(tert-butyl)phenyl]isoquinolin-1-amine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-N-(4-tert-butylphenyl)isoquinolin-1-amine; 848841-47-4; 6-Fluoro-N-(4-tert-butylphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine; Boronic ester intermediate CAS 848841-47-4; Pinacol boronate isoquinoline derivative
EINECS	Contact for details

Quality Control

Every batch of n-(4-tert-Butylphenyl)-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthetic applications. A detailed Certificate of Analysis (COA) with HPLC purity, NMR, and mass spec confirmation is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.