Description

2,3,4,5,6-Pentafluorophenyl 4-Bromobenzenesulfonate is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonate ester and halogenated aromatic structure. This compound is critical for introducing the pentafluorophenoxy (PFP) leaving group in advanced synthetic chemistry, enabling efficient coupling reactions under mild conditions. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in nucleoside and protease inhibitor research.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the pentafluorophenyl moiety enhances biological activity and stability.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent for producing specialty fluorinated polymers with unique surface properties and chemical resistance.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and molecular recognition studies.
• Peptide & Protein Modification: Acts as an efficient reagent for labeling and conjugating biomolecules due to its high reactivity with amines and thiols.
• Material Science Research: Utilized in the development of advanced organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: A valuable tool for creating activity-based probes and diagnostic agents.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 4-Bromobenzenesulfonate
CAS No.	848649-38-7
Molecular Formula	C12H4BrF5O3S
Molecular Weight	403.12 g/mol
Synonyms	4-Bromobenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl 4-Bromobenzenesulfonate; 4-Bromophenylsulfonyl Pentafluorophenyl Ester; 4-Bromo-Benzenesulfonic Acid Pentafluorophenyl Ester; PFP-4-Bromobenzenesulfonate; 848649-38-7; 4-Bromobenzene-1-sulfonyl Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2,3,4,5,6-Pentafluorophenyl 4-Bromobenzenesulfonate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.