Description

1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic frameworks. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing novel pyrazole-containing active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that incorporate the 1-methylpyrazole moiety.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or organic semiconductors.
• Chemical Biology: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel N-heterocyclic carbene (NHC) or other ligand systems for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-molecule libraries.

Basic Information

Product Name	1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester
CAS No.	847818-74-0
Molecular Formula	C₁₀H₁₇BN₂O₂
Molecular Weight	208.07 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methyl-1H-pyrazol-5-ylboronic acid pinacol ester; 1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methylpyrazole-5-boronic acid pinacol ester; 5-Borono-1-methyl-1H-pyrazole pinacol ester; Pyrazole boronic ester, 1-methyl-
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening a new container to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.