Description

cis-4-(Boc-Amino)Cyclohexaneacetaldehyde is a high-purity, protected amino aldehyde building block used in advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the construction of complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on peptide mimetics, constrained analogs, and other bioactive compounds requiring a rigid, functionalized cyclohexane scaffold.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Peptidomimetics Synthesis: Used to introduce constrained, non-natural amino acid residues into peptide chains to enhance metabolic stability and binding affinity.
• Ligand and Probe Development: Serves as a precursor for creating specialized chemical probes and high-affinity ligands for biochemical assays and target validation.
• Asymmetric Synthesis: Employed in stereoselective reactions, including reductive amination and nucleophilic addition, to construct complex chiral centers.
• Chemical Biology Research: Utilized in the design and synthesis of tool compounds for studying protein-protein interactions and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing custom intermediates under cGMP conditions.

Basic Information

Product Name	cis-4-(Boc-Amino)Cyclohexaneacetaldehyde
CAS No.	847417-37-2
Molecular Formula	C₁₃H₂₃NO₃
Molecular Weight	241.33 g/mol
Synonyms	4-[(tert-Butoxycarbonyl)amino]cyclohexaneacetaldehyde; 4-[(Boc)amino]cyclohexaneacetaldehyde; cis-4-(N-Boc-amino)cyclohexaneacetaldehyde; (cis-4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetaldehyde; 4-(Boc-amino)cyclohexaneacetaldehyde; 4-(tert-Butoxycarbonylamino)cyclohexylacetaldehyde; (4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetaldehyde; Boc-4-Aca-CHO
EINECS	Contact for details

Quality Control

Our cis-4-(Boc-Amino)Cyclohexaneacetaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation and light. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.