Description

Methyl 4-[7-Fluoro-2-(3-Isopropoxypropyl)-3,9-dioxo-1,2,3,9-tetrahydrochromeno[2,3-c]pyrrol-1-yl]benzoate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key building block with a complex fused heterocyclic structure. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of proprietary drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with targeted biological activity.
• API Development: Integral to the process development and scale-up of new active pharmaceutical ingredients requiring its specific chromenopyrrole scaffold.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: May be used as a reference standard or probe compound in biochemical assays to study enzyme inhibition or receptor binding.

Basic Information

Product Name	Methyl 4-[7-Fluoro-2-(3-Isopropoxypropyl)-3,9-Dioxo-1,2,3,9-Tetrahydrochromeno[2,3-C]Pyrrol-1-Yl]Benzoate
CAS No.	847183-80-6
Molecular Formula	C25H24FNO6
Molecular Weight	453.46 g/mol
Synonyms	Methyl 4-(7-fluoro-2-(3-isopropoxypropyl)-3,9-dioxo-1,2,3,9-tetrahydrochromeno[2,3-c]pyrrol-1-yl)benzoate; 1H-Chromeno[2,3-c]pyrrole-1-carboxylic acid, 2,3,9,9a-tetrahydro-7-fluoro-2-[3-(1-methylethoxy)propyl]-3,9-dioxo-, phenylmethyl ester; Benzoic acid, 4-[7-fluoro-2-[3-(1-methylethoxy)propyl]-3,9-dioxo-2,3,9,9a-tetrahydro-1H-chromeno[2,3-c]pyrrol-1-yl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 4-[7-Fluoro-2-(3-Isopropoxypropyl)-3,9-dioxo-1,2,3,9-tetrahydrochromeno[2,3-c]pyrrol-1-yl]benzoate adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. The product is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your regulatory and quality documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.