Description

4'-Chloro-2'-Methyl-2,2,2-Trifluoroacetophenone is a high-value fluorinated aromatic ketone building block, distinguished by its unique trifluoromethyl and chloro-methyl substitution pattern. This compound is critical for its role in facilitating efficient synthetic routes to complex molecules, offering enhanced metabolic stability and lipophilicity in target structures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of trifluoromethyl-containing active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, leveraging its aromatic and fluorinated properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, Friedel-Crafts acylation, and as a precursor for heterocyclic compounds in academic and industrial research.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on chemical reactivity and physical properties in molecular design.

Basic Information

Product Name	4'-Chloro-2'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	845823-13-4
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	1-(4-Chloro-2-methylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-chloro-2-methylphenyl)ethanone; 4-Chloro-2-methyl-α,α,α-trifluoroacetophenone; 4-Chloro-2-methyltrifluoroacetophenone; 2-Methyl-4-chloro-α,α,α-trifluoroacetophenone; 4'-Chloro-2'-methyl-α,α,α-trifluoroacetophenone; 1-(4-Chloro-o-tolyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.