Description

2,2,2,3',5'-Pentafluoroacetophenone is a high-value fluorinated aromatic ketone building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique fluorine substitution pattern imparts desirable metabolic stability and lipophilicity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Building block for novel herbicides and pesticides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the development of fluorinated components for advanced display technologies.
• Organic Electronics: Serves as an intermediate for electron-transport materials and semiconductors.
• Cross-Coupling Reactions: Valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: Essential reagent for studying structure-activity relationships (SAR) in medicinal chemistry and material science.

Basic Information

Product Name	2,2,2,3',5'-Pentafluoroacetophenone
CAS No.	845823-12-3
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	1-(3,5-Difluorophenyl)-2,2,2-trifluoroethanone; 3',5'-Difluoro-2,2,2-trifluoroacetophenone; Pentafluoroacetophenone (unspecific isomer); α,α,α,3,5-Pentafluoroacetophenone; 2,2,2-Trifluoro-1-(3,5-difluorophenyl)ethanone; 3,5-Difluorophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 2,2,2,3',5'-Pentafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.