Description

4'-Fluoro-3'-Methyl-2,2,2-Trifluoroacetophenone is a high-value fluorinated aromatic ketone building block, prized for its unique trifluoromethyl and fluoro-substituted phenyl structure. This compound is critical for introducing lipophilicity, metabolic stability, and electronic effects into target molecules, making it a key intermediate in advanced synthesis. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry for CNS and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting protein kinases and other enzymes where the trifluoromethyl group enhances binding affinity and bioavailability.
• Agrochemical Active Ingredient Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where its fluorinated structure contributes to improved environmental stability and potency.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to the desired dielectric and luminescent properties.
• Advanced Polymer Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis Research: A versatile reagent in academic and industrial research for studying fluorination reactions and developing new catalytic methodologies.
• Fluorinated Liquid Crystal (LC) Dopant: Used in the formulation of high-performance LC mixtures for display applications, where it helps fine-tune electro-optical characteristics.

Basic Information

Product Name	4'-Fluoro-3'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	845823-10-1
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(4-Fluoro-3-methylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-fluoro-3-methylphenyl)ethanone; 4-Fluoro-3-methyl-α,α,α-trifluoroacetophenone; 3-Methyl-4-fluoro-α,α,α-trifluoroacetophenone; 1-(4-Fluoro-3-methylphenyl)-2,2,2-trifluoro-1-ethanone; 4-Fluoro-3-methyl-2,2,2-trifluoroacetophenone; 3'-Methyl-4'-fluoro-2,2,2-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-3'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.