Description

L-Proline, 4-Propoxy-, (4S)- (9Ci) is a chiral, non-proteinogenic amino acid derivative featuring a propoxy substitution at the 4-position of the proline ring. This structural modification makes it a valuable, high-purity building block for advanced pharmaceutical synthesis and biochemical research. It is specifically sought after by R&D chemists and process development scientists working in medicinal chemistry and peptide-based drug discovery. The compound's defined stereochemistry and functional group are critical for creating novel bioactive molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics & Drug Discovery: Used to introduce conformational constraints and enhance metabolic stability in peptide analogs and peptidomimetic drug candidates.
• Asymmetric Catalysis: Serves as a precursor or ligand component in the development of chiral catalysts for stereoselective synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to probe the function of proline-specific enzymes.
• Advanced Material Science: Potential use as a functionalized monomer for creating specialty polymers with unique chiral or biocompatible properties.

Basic Information

Product Name	L-Proline, 4-Propoxy-, (4S)- (9Ci)
CAS No.	845658-56-2
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	(4S)-4-Propoxy-L-proline; (S)-4-Propoxypyrrolidine-2-carboxylic acid; 4-Propoxy-L-proline; L-4-Propoxyproline; 4-Propoxy-(S)-proline; 4-n-Propoxy-L-proline; Pyrrolidine-2-carboxylic acid, 4-propoxy-, (2S)-
EINECS	Contact for details

Quality Control

Our production of L-Proline, 4-Propoxy-, (4S)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications, which typically include chiral purity, chemical purity, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.