Description

2-Bromo-1-Pyrimidin-4-Yl-Ethanone is a versatile brominated ketone building block featuring a pyrimidine heterocycle. This compound is of significant value in synthetic organic chemistry, particularly for the construction of complex molecules through nucleophilic substitution and cross-coupling reactions. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the pyrimidine scaffold.
• Material Science: Serves as a precursor for functionalized ligands and monomers in advanced polymeric materials.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the pyrimidinyl-acetyl moiety.
• Bioconjugation Chemistry: The reactive bromoacetyl group can be utilized for labeling and modifying biomolecules.

Basic Information

Product Name	2-Bromo-1-Pyrimidin-4-Yl-Ethanone
CAS No.	845504-81-6
Molecular Formula	C6H5BrN2O
Molecular Weight	201.02 g/mol
Synonyms	2-Bromo-1-(pyrimidin-4-yl)ethanone; 4-Acetylpyrimidine, 2-bromo-; 2-Bromo-1-(4-pyrimidinyl)ethanone; 1-(Pyrimidin-4-yl)-2-bromoethanone; 2-Bromo-4-pyrimidinyl methyl ketone; α-Bromo-4-pyrimidinyl methyl ketone; 4-(2-Bromoacetyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Pyrimidin-4-Yl-Ethanone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee it meets your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.