Description

1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a high-value, functionalized pyrazole derivative containing a pinacol boronate ester group, making it a versatile building block for advanced organic synthesis. This compound is critical for facilitating key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which is fundamental in modern pharmaceutical and materials science research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex heterocyclic cores.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides, a cornerstone methodology in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate functionalized pyrazole structures.
• Material Science & OLED Development: Acts as a building block for creating organic electronic materials, such as charge-transport layers or emissive materials in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: The pyrazole nitrogen atoms can coordinate to metals, making it useful for developing novel catalytic systems or metal-organic frameworks (MOFs).
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and bioconjugates for studying biological processes and target engagement.

Basic Information

Product Name	1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.	844891-04-9
Molecular Formula	C₁₄H₂₅BN₂O₂
Molecular Weight	264.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,5-trimethyl-1H-pyrazole; 1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1H-pyrazole; 1H-Pyrazole, 1,3,5-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Trimethylpyrazole pinacol boronate; 4-Pinacolatoboryl-1,3,5-trimethylpyrazole
EINECS	Contact for details

Quality Control

Every batch of 1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is manufactured and tested under strict quality management protocols to ensure high purity, lot-to-lot consistency, and reliable performance in sensitive synthetic applications. Our products undergo rigorous analytical testing, including NMR, HPLC, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.