Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane)-Pyrazole is a high-value organoboron building block, specifically a pyrazole-substituted pinacol boronate ester. This compound matters as a critical intermediate in modern synthetic chemistry, enabling efficient carbon-carbon and carbon-heteroatom bond formation via cross-coupling reactions. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research and development teams for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in Suzuki-Miyaura cross-coupling reactions to create biaryl and heteroaryl structures.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyrazole moiety is a common bioactive scaffold.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its ability to introduce functional boron groups.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes and inhibitors.
• Catalyst & Ligand Development: Utilized as a precursor for synthesizing novel N-heterocyclic carbene (NHC) ligands and other catalytic complexes.
• Academic & Contract Research: Essential for methodological development in organic synthesis laboratories and for custom synthesis projects.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane)-Pyrazole
CAS No.	844501-71-9
Molecular Formula	C9H15BN2O2
Molecular Weight	194.04 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-Pyrazoleboronic acid pinacol ester; 1H-Pyrazole-3-boronic acid, pinacol ester; 3-(Pinacolatoboryl)-1H-pyrazole; Pyrazole-3-boronic acid pinacol ester; 3-Boronopyrazole pinacol ester; 3-Pyrazolylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane)-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.