Description

n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Methanesulfonamide is a high-purity, synthetically valuable boronic ester derivative, specifically designed as a key building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation through Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides by facilitating the introduction of the benzyl-methanesulfonamide pharmacophore.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to efficiently create biaryl and heterobiaryl structures.
• Chemical Biology & Proteomics: Utilized as a versatile handle for bioconjugation and the development of chemical probes and enzyme inhibitors.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel bidentate ligands used in asymmetric catalysis.

Basic Information

Product Name	n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Methanesulfonamide
CAS No.	843646-66-2
Molecular Formula	C14H22BNO4S
Molecular Weight	311.21 g/mol
Synonyms	N-[[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]methanesulfonamide; 3-[(Methanesulfonylamino)methyl]phenylboronic acid pinacol ester; N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)methanesulfonamide; Methanesulfonamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-; (3-((Methylsulfonamido)methyl)phenyl)boronic acid pinacol ester; B-[3-[(Methylsulfonylamino)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]Methanesulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for each shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.