Description

n-(2-Dimethylaminoethyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety makes it an essential reagent for palladium-catalyzed carbon-carbon bond formation in organic synthesis.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• API Development & Scale-up: Employed in process chemistry for the pilot-scale and commercial-scale production of target pharmaceutical compounds.
• Chemical Biology Probes: Can be utilized to create labeled molecules or probes for studying biological pathways and target engagement.
• Material Science Research: Potential use in the synthesis of organic electronic materials and polymers where precise molecular architecture is required.

Basic Information

Product Name	n-(2-Dimethylaminoethyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	840521-76-8
Molecular Formula	C19H31BN2O3
Molecular Weight	346.28 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[2-(dimethylamino)ethyl]benzamide; N-[2-(Dimethylamino)ethyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; Benzamide, N-[2-(dimethylamino)ethyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 840521-76-8; 3-Pinacolatoboryl-N-(2-dimethylaminoethyl)benzamide; Boronic acid, B-[3-[[[2-(dimethylamino)ethyl]amino]carbonyl]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our n-(2-Dimethylaminoethyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing all specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.