Description

1H-Imidazole-4-Carboxylic Acid, 5-(Trifluoromethyl)- is a high-value trifluoromethylated heterocyclic building block, offering unique electronic and steric properties for advanced molecular design. Its core value lies in enabling the synthesis of novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for functionalized polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology Probe Development: Employed to create tagged molecules for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	1H-Imidazole-4-Carboxylic Acid, 5-(Trifluoromethyl)-
CAS No.	840490-23-5
Molecular Formula	C5H3F3N2O2
Molecular Weight	180.09 g/mol
Synonyms	5-(Trifluoromethyl)-1H-imidazole-4-carboxylic acid; 5-(Trifluoromethyl)-4-imidazolecarboxylic acid; 4-Carboxy-5-(trifluoromethyl)imidazole; 5-Trifluoromethyl-1H-imidazole-4-carboxylic acid; 1H-Imidazole-4-carboxylic acid, 5-(trifluoromethyl)-; 840490-23-5
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carboxylic Acid, 5-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.