Description

6-Ethoxy-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated and ethoxy-substituted biaryl compounds, which are common scaffolds in drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs or semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create fluorophore-conjugated or bioactive molecules for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	6-Ethoxy-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	840481-76-7
Molecular Formula	C15H19BFNO3
Molecular Weight	291.13 g/mol
Synonyms	2-Fluoro-6-ethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 3-Cyano-2-fluoro-6-ethoxyphenylboronic acid pinacol ester; (3-Cyano-2-fluoro-6-ethoxyphenyl)boronic acid pinacol ester; Boronic acid, B-(3-cyano-2-fluoro-6-ethoxyphenyl)-, 1,1-dimethylethyl ester; 6-Ethoxy-2-fluoro-3-(pinacolatoboryl)benzonitrile; 840481-76-7; Pinacol 6-Ethoxy-2-fluoro-3-cyanophenylboronate
EINECS	Contact for details

Quality Control

Our 6-Ethoxy-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.