Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline-1-Carboxylate is a high-purity, protected indoline boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex carbon-carbon bonds in pharmaceutical and advanced material synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality building blocks for drug discovery and the development of novel organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing functionalized indoline scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the efficient and selective formation of biaryl and heterobiaryl bonds, a cornerstone reaction in medicinal chemistry and material science.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require complex heterocyclic structures.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transport or host materials in the fabrication of advanced display and lighting technologies.
• Ligand and Catalyst Development: Useful for constructing novel chiral or functionalized ligands used in asymmetric catalysis.
• Academic and Contract Research: A valuable reagent for methodology development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline-1-Carboxylate
CAS No.	837392-67-3
Molecular Formula	C19H28BNO4
Molecular Weight	345.24 g/mol
Synonyms	1-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole-1-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; 1-Boc-5-(pinacolboryl)indoline; 5-Pinacolatoboron-1-Boc-indoline; 5-Boron-indoline-1-carboxylic acid tert-butyl ester, pinacol ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and mass spectrometry to ensure identity and quality. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.