Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl) Indolin-2-One is a high-value pharmaceutical intermediate and versatile synthetic building block featuring a pinacol boronate ester group. This compound is essential for modern medicinal chemistry, enabling efficient cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, enabling the introduction of the indolinone scaffold.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Employed in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to R&D and pilot-scale production.
• Academic & Industrial R&D: Fundamental reagent in organic synthesis laboratories for methodology development and complex molecule construction.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl) Indolin-2-One
CAS No.	837392-64-0
Molecular Formula	C14H18BNO3
Molecular Weight	259.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-indol-2-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one; 2-Oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 5-(Pinacolatoboryl)indolin-2-one; 5-Indolin-2-oneboronic acid pinacol ester; 5-Boronopinacol indolin-2-one; 837392-64-0; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-indolinone
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl) Indolin-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.