Description

2-Trifluoromethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, multi-functional indole-based boronic ester building block. This compound is critical for modern synthetic chemistry, enabling the efficient construction of complex molecular architectures through versatile cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for Suzuki-Miyaura cross-coupling reactions in the synthesis of drug candidates, particularly those containing indole and trifluoromethyl motifs.
• Agrochemical Research: Used to create novel herbicides, fungicides, and insecticides by introducing the indole-boronate core into lead structures.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors, where the indole unit contributes to charge transport properties.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronate handle.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and catalysis studies within university and CRO laboratories.
• Ligand Synthesis: Used to construct complex ligands for catalysis, including those for asymmetric synthesis and transition metal complexes.

Basic Information

Product Name	2-Trifluoromethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	837392-61-7
Molecular Formula	C15H17BF3NO2
Molecular Weight	311.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)-1H-indole; 2-Trifluoromethyl-1H-indole-5-boronic acid pinacol ester; 2-(Trifluoromethyl)-1H-indole-5-boronic acid pinacol ester; 1H-Indole-5-boronic acid, 2-(trifluoromethyl)-, 1,1-dimethylethyl ester; 837392-61-7; 2-CF3-5-Bpin-indole; 5-Bpin-2-CF3-indole
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure high purity and consistency for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.