Description

2-Dioxaborolan-2-Yl)-1H-Indole is a specialized organoboron building block featuring an indole core functionalized with a pinacol boronate ester group. This compound is of significant value in modern synthetic chemistry, particularly in cross-coupling reactions, due to its stability and reactivity profile. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel drug candidates, especially those containing functionalized indole moieties.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is critical.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules or in the synthesis of molecular probes for diagnostic applications.
• Scale-up Process Chemistry: Suitable for use in kilo-lab and pilot plant settings for the production of target molecules at larger scales under GMP-like conditions.

Basic Information

Product Name	2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	837392-56-0
Molecular Formula	C14H16BNO2
Molecular Weight	241.10 g/mol
Synonyms	1H-Indole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; Indole-2-boronic acid pinacol ester; 2-(1,3,2-Dioxaborolan-2-yl)-1H-indole, 4,4,5,5-tetramethyl-; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 2-Indolylboronic acid pinacol ester; PINACOL 2-INDOLYLBORONATE; 2-(2-Pinacolatoboryl)-1H-indole
EINECS	Contact for details

Quality Control

Our 2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can supply material compliant with various internal quality standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.