Description

1H-Indole, 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value indole-based boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating complex indole-containing heterocycles for oncology and CNS therapeutics.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products, leveraging its structural motif for bioactivity.
• Material Science Research: Serves as a precursor for organic semiconductors, OLED materials, and other functional organic materials where the indole-boronate moiety is incorporated.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling, enabling the efficient and selective formation of biaryl and other conjugated systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and protein interactions.
• Academic & Industrial R&D: A fundamental tool for method development and exploratory synthesis in both university laboratories and industrial R&D centers.

Basic Information

Product Name	1H-Indole, 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	837392-54-8
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1H-indole; 2-Methyl-1H-indole-5-boronic acid pinacol ester; 2-Methylindole-5-boronic acid pinacol ester; 5-Borono-2-methylindole pinacol ester; Pinacol 2-methyl-1H-indole-5-boronate; (2-Methyl-1H-indol-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Indole, 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We are committed to supplying material that meets the stringent requirements of research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by titration)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.